Skip to main content
Back to Investors

Two Sigma Ventures Portfolio Companies

Investor actively backing innovative startups and growth-stage companies across various industries and funding rounds.

Last updated: July 2026

Two Sigma Ventures Investment Overview

Portfolio Companies
108
Total Invested
$2.9B
Average Investment
$39.8M

Two Sigma Ventures's Most Recent Investments (2020+)

Company NameFoundedFunding StageAmountCity
Crossover Markets Group2024Series A$12.0MLondon
treet2024Series A$10.0MSan Francisco
Ansel Health2024Venture - Series Unknown$20.0MClaymont
Objective2023Seed$13.0MSan Francisco
Membrane Labs2023Series A$20.0MNew York
Switchboard Software2023Series A$7.0MSan Francisco
Freeform2026Venture - Series Unknown$58.9MLos Angeles
Exai Bio2021Series AUndisclosedPalo Alto
NewtonX2021Series BUndisclosedNew York
Okteto2022Series AUndisclosedSan Francisco

Complete List of Two Sigma Ventures Portfolio Companies (108)

Export
#CompanyStageAmountLocation
26Crossover Markets GroupSeries A$12.0MLondon, United Kingdom
27treetSeries A$10.0MSan Francisco, United States
28Ansel HealthVenture - Series Unknown$20.0MClaymont, United States
29ObjectiveSeed$13.0MSan Francisco, United States
30Membrane LabsSeries A$20.0MNew York, United States
31Switchboard SoftwareSeries A$7.0MSan Francisco, United States
32FreeformVenture - Series Unknown$58.9MLos Angeles, United States
33Exai BioSeries AUndisclosedPalo Alto, United States
34NewtonXSeries BUndisclosedNew York, United States
35OktetoSeries AUndisclosedSan Francisco, United States
Financial Services

Crossover Markets Group is a digital asset exchange designed to meet the liquidity needs of institutional clients.

London, United Kingdom
June 2024
$12.0M
Series A

Founder Contacts

19,000+ verified contacts

E-CommerceE-Commerce PlatformsFashionRetail

Treet helps modern brands grow responsibly through resale

San Francisco, United States
March 2024
$10.0M
Series A

Founder Contacts

19,000+ verified contacts

Financial ServicesHealth InsuranceInsuranceInsurTechSoftware

Ansel Health is a developer of a health insurance platform intended for employers to enhance their employee benefits.

Claymont, United States
January 2024
$20.0M
Venture - Series Unknown

Founder Contacts

19,000+ verified contacts

Artificial Intelligence (AI)Machine LearningProduct SearchSearch EngineSemantic SearchVertical SearchVisual Search

Objective is a firm that focuses on AI-native search solutions for websites and applications.

San Francisco, United States
October 2023
$13.0M
Seed

Founder Contacts

19,000+ verified contacts

Financial ServicesFinTechLending

Membrane Labs is a fintech firm that provides institutional digital asset services for OTC transactions.

New York, United States
October 2023
$20.0M
Series A

Founder Contacts

19,000+ verified contacts

AnalyticsBig DataCloud Data ServicesEnterprise SoftwareSaaS

Switchboard Software is an It firm that provides data engineering automation services to turn disparate data into a single source of truth.

San Francisco, United States
July 2023
$7.0M
Series A

Founder Contacts

19,000+ verified contacts

3D TechnologyElectronicsIndustrial AutomationMachinery ManufacturingRobotics

Freeform is a 3D printing company offering metal 3D printing solutions for manufacturing companies.

Los Angeles, United States
January 2026
$58.9M
Venture - Series Unknown

Founder Contacts

19,000+ verified contacts

BiotechnologyHealth CareHealth Diagnostics

Exai Bio is an orphan non-coding RNAs and AI-based liquid biopsy company.

Palo Alto, United States
December 2021
Series A

Founder Contacts

19,000+ verified contacts

B2BInformation ServicesInformation TechnologyManagement ConsultingMarket Research

The world’s leading businesses find their advantage with NewtonX. Make your next bold move with 100% verified B2B insights.

New York, United States
December 2021
Series B

Founder Contacts

19,000+ verified contacts

InternetMobile AppsSoftware

Okteto specializes in the fields of software development, software engineering, and the cloud computing industry.

San Francisco, United States
January 2022
Series A

Founder Contacts

19,000+ verified contacts

AnalyticsArtificial Intelligence (AI)Asset ManagementCyber SecurityElder CareHealth CareInternet of ThingsMedicalSoftwareWellness

Cylera is a healthcare IoT cybersecurity and intelligence company used to protect healthcare organizations.

New York, United States
December 2025
Convertible Note

Founder Contacts

19,000+ verified contacts

AnimationGraphic DesignSoftware

Rive is a real-time animation software provider.

San Francisco, United States
December 2025
Series A

Founder Contacts

19,000+ verified contacts

BiotechnologyNeurosciencePharmaceuticalTherapeutics

Cajal Neuroscience is a drug discovery company focused on neurodegenerative disease.

Seattle, United States
November 2022
Series A

Founder Contacts

19,000+ verified contacts

AppsEnterprise SoftwareSoftware Engineering

Freestyle is a software development company which builds full stack applications with exceptional infrastructure using typescript.

San Francisco, United States
January 2025
Seed

Founder Contacts

19,000+ verified contacts

AnalyticsEnterprise SoftwareProduct DesignProduct ManagementSaaSUX Design

Candu is a product experience platform for software teams who want to design, refine, and personalize their application’s user interface.

San Francisco, United States
November 2024
Undisclosed

Founder Contacts

19,000+ verified contacts

AI InfrastructureArtificial Intelligence (AI)Developer ToolsMachine LearningSoftware

Comet allows data scientists to automatically track their datasets, code changes, experimentation history, and production models.

New York, United States
November 2021
Series B

Founder Contacts

19,000+ verified contacts

AnalyticsArtificial Intelligence (AI)Machine LearningSoftware

Indico Data provides machine learning solutions for automating data extraction and analysis from unstructured content.

Boston, United States
October 2025
Venture - Series Unknown

Founder Contacts

19,000+ verified contacts

BiotechnologyHealth CareTherapeutics

Hexagon Bio is a data-driven biotech company developing targeted small molecule therapeutics.

Menlo Park, United States
October 2022
Series B

Founder Contacts

19,000+ verified contacts

Artificial Intelligence (AI)Cyber SecurityDeveloper ToolsGenerative AI

Nullify is a cybersecurity technology company that provides an autonomous AI-powered workforce to automate product security tasks.

Sydney, Australia
February 2026
$12.5M
Seed

Founder Contacts

19,000+ verified contacts

Consumer ElectronicsFitnessSportsWearablesWellness

WHOOP is a fitness tech company that offers wearables that track sleep, recovery, and performance.

Boston, United States
January 2026
Undisclosed

Founder Contacts

19,000+ verified contacts

AI InfrastructureArtificial Intelligence (AI)ComputerHardwareSemiconductor

Etched.ai is an AI chip startup that develops Sohu, a chip designed specifically for running transformer models.

Cupertino, United States
January 2026
$500.0M
Series Unknown

Founder Contacts

19,000+ verified contacts

Artificial Intelligence (AI)Computer VisionGenerative AIKnowledge ManagementMachine Learning

Pryon is an enterprise knowledge management platform designed to simplify and accelerate the adoption of artificial intelligence.

Raleigh, United States
December 2025
Convertible Note

Founder Contacts

19,000+ verified contacts

Artificial Intelligence (AI)Renewable EnergySolar

Cosmos Innovation specialize in full stack software development, product design, cloud hosting, and MVP deployment.

Seattle, United States
November 2025
Series Unknown

Founder Contacts

19,000+ verified contacts

Cloud SecurityCyber SecurityEnterprise SoftwareIdentity Management

Cerby is the identity automation platform for disconnected apps

San Francisco, United States
September 2025
Series B

Founder Contacts

19,000+ verified contacts

BiotechnologyPharmaceuticalTherapeutics

Enveda Biosciences is a biotechnology company that develops novel medications derived from plants.

Boulder, United States
September 2025
$150.0M
Series D

Founder Contacts

19,000+ verified contacts

Showing 26-50 of 108 portfolio companies

Frequently Asked Questions About Two Sigma Ventures

How many companies has Two Sigma Ventures invested in?

Two Sigma Ventures has invested in 108 companies tracked in our database. The portfolio spans multiple industries and funding stages, from seed-stage startups to late-stage companies.

What industries does Two Sigma Ventures invest in?

Two Sigma Ventures's top investment sectors include Artificial Intelligence (AI), Software, Machine Learning, Analytics, Enterprise Software. The firm invests across 70 different industry categories.

What is Two Sigma Ventures's largest investment?

Among tracked funding rounds, Etched.ai received $500.0M in a Series Unknown round. Two Sigma Ventures's total known invested capital is $2.9B.

What is the average investment size for Two Sigma Ventures?

Two Sigma Ventures's average investment size is $39.8M across its portfolio of 108 companies.

What are Two Sigma Ventures's most recent investments?

Recent Two Sigma Ventures portfolio additions include Crossover Markets Group, treet, Ansel Health, Objective, Membrane Labs. These companies were founded in 2020 or later.

Explore Other Top Investors

Discover portfolio companies of other leading venture capital firms and investors.

View All Investors