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Two Sigma Ventures Portfolio Companies

Investor actively backing innovative startups and growth-stage companies across various industries and funding rounds.

Last updated: July 2026

Two Sigma Ventures Investment Overview

Portfolio Companies
88
Total Invested
$2.9B
Average Investment
$39.8M

Two Sigma Ventures's Most Recent Investments (2020+)

Company NameFoundedFunding StageAmountCity
Switchboard Software2023Series A$7.0MSan Francisco
Kallyope2023Grant$8.2MNew York
Isabl Inc.2023Grant$2.0MNew York
Socure2023Debt Financing$95.0MIncline Village
C3 Exchange2023Seed$6.0MGrand Cayman
Cajal Neuroscience2022Series A$96.0MSeattle
Nelo2022Debt Financing$100.0MMexico City
Hexagon Bio2022Series B$77.3MMenlo Park
Flatfile2022Series B$50.0MDenver
Rift Finance2022Series Unknown$18.0MNew York

Complete List of Two Sigma Ventures Portfolio Companies (88)

Export
#CompanyStageAmountLocation
51Switchboard SoftwareSeries A$7.0MSan Francisco, United States
52KallyopeGrant$8.2MNew York, United States
53Isabl Inc.Grant$2.0MNew York, United States
54SocureDebt Financing$95.0MIncline Village, United States
55C3 ExchangeSeed$6.0MGrand Cayman, Cayman Islands
56Cajal NeuroscienceSeries A$96.0MSeattle, United States
57NeloDebt Financing$100.0MMexico City, Mexico
58Hexagon BioSeries B$77.3MMenlo Park, United States
59FlatfileSeries B$50.0MDenver, United States
60Rift FinanceSeries Unknown$18.0MNew York, United States
AnalyticsBig DataCloud Data ServicesEnterprise SoftwareSaaS

Switchboard Software is an It firm that provides data engineering automation services to turn disparate data into a single source of truth.

San Francisco, United States
July 2023
$7.0M
Series A

Founder Contacts

19,000+ verified contacts

BiotechnologyHealth CareMedicalPharmaceutical

Kallyope uses the science of gut-brain biology to create medicines that transform human health.

New York, United States
May 2023
$8.2M
Grant

Founder Contacts

19,000+ verified contacts

BiotechnologyHealth DiagnosticsHospitalMedicalOncology

Isabl develops cancer diagnostic tests based on whole genome and RNA sequencing data.

New York, United States
April 2023
$2.0M
Grant

Founder Contacts

19,000+ verified contacts

Artificial Intelligence (AI)Cyber SecurityFraud DetectionIdentity ManagementInformation ServicesInformation TechnologyMachine LearningPredictive Analytics

Socure is a predictive analytics platform for digital identity verification of consumers.

Incline Village, United States
March 2023
$95.0M
Debt Financing

Founder Contacts

19,000+ verified contacts

Financial Services

C3 is self-custodial exchange offering the benefits of decentralization with the performance and accessibility of traditional exchanges.

Grand Cayman, Cayman Islands
February 2023
$6.0M
Seed

Founder Contacts

19,000+ verified contacts

BiotechnologyNeurosciencePharmaceuticalTherapeutics

Cajal Neuroscience is a drug discovery company focused on neurodegenerative disease.

Seattle, United States
November 2022
$96.0M
Series A

Founder Contacts

19,000+ verified contacts

FinanceFinancial ServicesFinTechInformation TechnologyMobile AppsMobile Payments

Nelo increases the buying power for consumers in LatAm. Backed by Two Sigma Ventures, Homebrew, Susa Ventures, and more.

Mexico City, Mexico
October 2022
$100.0M
Debt Financing

Founder Contacts

19,000+ verified contacts

BiotechnologyHealth CareTherapeutics

Hexagon Bio is a data-driven biotech company developing targeted small molecule therapeutics.

Menlo Park, United States
October 2022
$77.3M
Series B

Founder Contacts

19,000+ verified contacts

Cloud Data ServicesCRMManagement Information SystemsSaaSSoftware

Flatfile is a software development company that provides AI-assisted data exchange and API-ready data solutions online.

Denver, United States
September 2022
$50.0M
Series B

Founder Contacts

19,000+ verified contacts

BlockchainCryptocurrencyFinanceFinancial Services

Rift Finance is a decentralized protocol that supercharges DAO growth through restructured incentive frameworks.

New York, United States
February 2022
$18.0M
Series Unknown

Founder Contacts

19,000+ verified contacts

BiotechnologyHealth CareHealth Diagnostics

Exai Bio is an orphan non-coding RNAs and AI-based liquid biopsy company.

Palo Alto, United States
December 2021
$67.5M
Series A

Founder Contacts

19,000+ verified contacts

BillingSaaSSoftware

MonetizeNow is the World's First Unified CPQ, Billing and Usage Platform Built For B2B SaaS

Santa Clara, United States
November 2021
$3.0M
Seed

Founder Contacts

19,000+ verified contacts

Human ResourcesSmall and Medium BusinessesSoftware

Sora is a low-code intelligent workflow automation and data integration tool that connects different corporate applications.

San Francisco, United States
August 2021
$14.0M
Series A

Founder Contacts

19,000+ verified contacts

FinTechInsuranceInsurTech

Agentero is creating a smarter, more intuitive insurance ecosystem

Berkeley, United States
July 2021
$13.5M
Series A

Founder Contacts

19,000+ verified contacts

Cloud InfrastructureDeveloper ToolsEnterprise SoftwareSoftware

Replicated provides a platform for delivering and managing Kubernetes applications in any environment.

West Hollywood, United States
July 2021
$50.0M
Series C

Founder Contacts

19,000+ verified contacts

Clinical TrialsHealth CareMedicalPharmaceuticalSoftwareTherapeutics

Castor offers a cloud-based clinical data platform that simplifies and streamlines clinical trials processes.

Amsterdam, The Netherlands
July 2021
$45.0M
Series B

Founder Contacts

19,000+ verified contacts

BiotechnologyHealth CareLife SciencePharmaceutical

Appia Bio is a biotechnology company that focuses on the research and development of off-the-shelf allogeneic cell therapies.

Los Angeles, United States
May 2021
$52.0M
Series A

Founder Contacts

19,000+ verified contacts

E-CommerceMobile AppsSoftware

The AI operating system for SMBs and franchise brands.

Brooklyn, United States
April 2021
$2.3M
Seed

Founder Contacts

19,000+ verified contacts

Cyber SecurityRisk ManagementSecuritySoftware

SecurityScorecard is a cybersecurity platform used for predicting and remediating potential security risks.

New York, United States
March 2021
$180.0M
Series E

Founder Contacts

19,000+ verified contacts

Cloud ComputingConsumerConsumer ApplicationsElder CareHome Health CareLast Mile TransportationPetProperty ManagementSaaSSmart Home

Smartfrog Group is the original consumer IoT SaaS pioneer with IoT users in over 180 countries.

New York, United States
December 2020
$36.6M
Series Unknown

Founder Contacts

19,000+ verified contacts

Artificial Intelligence (AI)Big DataBioinformaticsMachine LearningRobotics

Zymergen is a biotechnology company that specializes in machine learning, big data, and artificial intelligence.

Emeryville, United States
September 2020
$300.0M
Series D

Founder Contacts

19,000+ verified contacts

CryptocurrencyFinance

Risk Labs is the foundation and core team behind the Across and UMA Protocols.

Ottawa, Canada
July 2020
Series Unknown

Founder Contacts

19,000+ verified contacts

Cloud ComputingConsumerConsumer ApplicationsElder CareElderlyInternetInternet of ThingsSaaSSoftware

Canary is a NYC-based subsidiary of Smartfrog Group the original consumer IoT SaaS pioneer with IoT users in over 180 countries.

New York, United States
July 2020
Corporate Round

Founder Contacts

19,000+ verified contacts

Artificial Intelligence (AI)Generative AI

Scaling AI to the Real World.

Palo Alto, United States
May 2020
$65.0M
Undisclosed

Founder Contacts

19,000+ verified contacts

Big DataDeveloper APIsEnterprise SoftwareFinTechMachine LearningOpen Source

Enigma provides reliable data and insights on the identity, activity, and risk profile of every small business.

New York, United States
June 2019
Series Unknown

Founder Contacts

19,000+ verified contacts

Showing 51-75 of 88 portfolio companies

Frequently Asked Questions About Two Sigma Ventures

How many companies has Two Sigma Ventures invested in?

Two Sigma Ventures has invested in 88 companies tracked in our database. The portfolio spans multiple industries and funding stages, from seed-stage startups to late-stage companies.

What industries does Two Sigma Ventures invest in?

Two Sigma Ventures's top investment sectors include Software, Biotechnology, SaaS, Health Care, Pharmaceutical. The firm invests across 61 different industry categories.

What is Two Sigma Ventures's largest investment?

Among tracked funding rounds, Zymergen received $300.0M in a Series D round. Two Sigma Ventures's total known invested capital is $2.9B.

What is the average investment size for Two Sigma Ventures?

Two Sigma Ventures's average investment size is $39.8M across its portfolio of 88 companies.

What are Two Sigma Ventures's most recent investments?

Recent Two Sigma Ventures portfolio additions include Switchboard Software, Kallyope, Isabl Inc., Socure, C3 Exchange. These companies were founded in 2020 or later.

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