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Big Brain Holdings Portfolio Companies

Investor actively backing innovative startups and growth-stage companies across various industries and funding rounds.

Last updated: July 2026

Big Brain Holdings Investment Overview

Portfolio Companies
25
Total Invested
$388.3M
Average Investment
$5.4M

Big Brain Holdings's Most Recent Investments (2020+)

Company NameFoundedFunding StageAmountCity
Ultrade2022SeedUndisclosedNew York
BIO Protocol2025SeedUndisclosedNew York
Distributed2022SeedUndisclosedLondon
Fig Investments2022Pre-SeedUndisclosedVancouver
Ludex2022Pre-SeedUndisclosedMontréal
Akave2026Seed$6.7MWilmington
Perle AI2025Seed$9.0MSan Francisco
Acre2025Venture - Series Unknown$4.0MSan Francisco
FrodoBots Lab2025Seed$6.0MWeston
Sphere2024Venture - Series Unknown$5.0MBoston

Complete List of Big Brain Holdings Portfolio Companies (25)

Export
#CompanyStageAmountLocation
1UltradeSeedUndisclosedNew York, United States
2BIO ProtocolSeedUndisclosedNew York, United States
3DistributedSeedUndisclosedLondon, United Kingdom
4Fig InvestmentsPre-SeedUndisclosedVancouver, Canada
5LudexPre-SeedUndisclosedMontréal, Canada
6AkaveSeed$6.7MWilmington, United States
7Perle AISeed$9.0MSan Francisco, United States
8AcreVenture - Series Unknown$4.0MSan Francisco, United States
9FrodoBots LabSeed$6.0MWeston, United States
10SphereVenture - Series Unknown$5.0MBoston, United States
BlockchainEnterprise Software

Ultrade is an online trading platform intended for Defi, on algorand blockchain.

New York, United States
September 2022
Seed

Founder Contacts

19,000+ verified contacts

BiotechnologyBlockchainFinance

BIO Protocol is a pioneering platform that uses blockchain technology to transform early-stage scientific research finance.

New York, United States
September 2025
Seed

Founder Contacts

19,000+ verified contacts

BlockchainSoftware

We build and acquire category-defining businesses in the Web3 space, with a primary focus on Algorand.

London, United Kingdom
August 2022
Seed

Founder Contacts

19,000+ verified contacts

BlockchainFinancial ServicesFinTechSoftware

Fig is a technology platform that helps financial services firms offer crypto structured & direct indexing products

Vancouver, Canada
July 2022
Pre-Seed

Founder Contacts

19,000+ verified contacts

CryptocurrencyVideo Games

Ludex protocols enable Video Game Devs to handle on-chain Token transactions with no blockchain experience required.

Montréal, Canada
April 2022
Pre-Seed

Founder Contacts

19,000+ verified contacts

BitcoinBlockchainNetwork Security

Akave is an enterprise cloud infrastructure company that combines blockchain verifiability with S3-compatible object storage.

Wilmington, United States
March 2026
$6.7M
Seed

Founder Contacts

19,000+ verified contacts

Artificial Intelligence (AI)Information TechnologyInternet

Perle AI offers an AI training data platform that provides data solutions at scale for developing specialized AI applications.

San Francisco, United States
August 2025
$9.0M
Seed

Founder Contacts

19,000+ verified contacts

BlockchainDecentralized Finance (DeFi)Web3

Acre provides users with the opportunity to deposit their Bitcoin assets in order to generate additional Bitcoin.

San Francisco, United States
February 2025
$4.0M
Venture - Series Unknown

Founder Contacts

19,000+ verified contacts

Artificial Intelligence (AI)Information TechnologyRobotics

FrodoBots Lab is a pioneer in crowdsourcing robotics data through gaming.

Weston, United States
February 2025
$6.0M
Seed

Founder Contacts

19,000+ verified contacts

B2BBlockchainPaymentsSoftware

The operating system for stablecoins.

Boston, United States
December 2024
$5.0M
Venture - Series Unknown

Founder Contacts

19,000+ verified contacts

BlockchainWeb3

Initia is a network for 0-to-1 omnichain rollups built by fusing a novel L1 with an interwoven application-specific L2 infrastructure.

Singapore, Singapore
September 2024
$14.0M
Series A

Founder Contacts

19,000+ verified contacts

BlockchainDecentralized Finance (DeFi)Information Technology

Mitosis offers an L1 network meant to revolutionize on-chain asset management.

Panama, United States
May 2024
$7.0M
Seed

Founder Contacts

19,000+ verified contacts

BlockchainDecentralized Finance (DeFi)FinanceInfrastructurePersonal FinanceSoftwareWeb3

Plena Finance is the first crypto Super App powered by Account Abstraction

Singapore, Singapore
April 2024
$5.0M
Seed

Founder Contacts

19,000+ verified contacts

Artificial Intelligence (AI)BlockchainMachine LearningWeb3

Inference Labs is advancing the use of zero-knowledge cryptography to guarantee the computational integrity of off-chain AI models.

Hamilton, Canada
April 2024
$2.3M
Seed

Founder Contacts

19,000+ verified contacts

Financial ServicesWeb3

Mayan builds cross-chain swap auction protocol.

Uccle, Belgium
April 2024
$3.0M
Seed

Founder Contacts

19,000+ verified contacts

BlockchainCryptocurrencyEthereum

Obscuro Labs develops the open-source platform, TEN. TEN is a Layer 2 rollup that hyper-scales and encrypts Ethereum.

London, United Kingdom
March 2024
$9.0M
Seed

Founder Contacts

19,000+ verified contacts

AnalyticsBlockchainCryptocurrencyInformation TechnologyInternetSoftwareWeb3

Helika is a Web3 technology and analytics platform.

Toronto, Canada
February 2024
$8.0M
Series A

Founder Contacts

19,000+ verified contacts

Information TechnologyWeb3

Sleek is a Hong Kong-based Web3 social networking platform that revolutionizes authentic human connection in the digital age.

Hong Kong, Hong Kong
November 2023
$5.0M
Seed

Founder Contacts

19,000+ verified contacts

Decentralized Finance (DeFi)Financial ServicesFinTech

Stix is the largest OTC platform for secondary market liquidity for Digital Assets

Warsaw, Poland
October 2023
$2.7M
Seed

Founder Contacts

19,000+ verified contacts

BlockchainCryptocurrencyGamingInformation TechnologyVideo Games

Third Time Entertainment is a startup game development studio that focused primarily on NFT and crypto gaming.

Orlando, United States
October 2023
$2.0M
Seed

Founder Contacts

19,000+ verified contacts

BlockchainCryptocurrency

Decentralized Social Graph

Hong Kong, Hong Kong
July 2023
$2.1M
Seed

Founder Contacts

19,000+ verified contacts

AppsBlockchain

Artela is an extensible blockchain network enabling developers to build feature rich dApps.

Fremont, United States
July 2023
$6.0M
Seed

Founder Contacts

19,000+ verified contacts

BlockchainCryptocurrencyPayments

TipLink is a lightweight wallet that helps send digital assets by sending an URL.

New York, United States
February 2023
$6.0M
Seed

Founder Contacts

19,000+ verified contacts

Generative AIHealth CareInternet

Outdefine -- The Learning and Execution Layer For Healthcare Systems.

San Francisco, United States
October 2023
Seed

Founder Contacts

19,000+ verified contacts

BlockchainCloud ManagementEthereum

MegaETH is an operator of a blockchain platform for traditional cloud computing servers.

Stanford, United States
October 2025
Initial Coin Offering

Founder Contacts

19,000+ verified contacts

Showing 1-25 of 25 portfolio companies

Frequently Asked Questions About Big Brain Holdings

How many companies has Big Brain Holdings invested in?

Big Brain Holdings has invested in 25 companies tracked in our database. The portfolio spans multiple industries and funding stages, from seed-stage startups to late-stage companies.

What industries does Big Brain Holdings invest in?

Big Brain Holdings's top investment sectors include Blockchain, Web3, Cryptocurrency, Information Technology, Software. The firm invests across 29 different industry categories.

What is Big Brain Holdings's largest investment?

Among tracked funding rounds, Initia Labs received $14.0M in a Series A round. Big Brain Holdings's total known invested capital is $388.3M.

What is the average investment size for Big Brain Holdings?

Big Brain Holdings's average investment size is $5.4M across its portfolio of 25 companies.

What are Big Brain Holdings's most recent investments?

Recent Big Brain Holdings portfolio additions include Ultrade, BIO Protocol, Distributed, Fig Investments, Ludex. These companies were founded in 2020 or later.

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