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Big Brain Holdings — Portfolio

Investor actively backing innovative startups and growth-stage companies across various industries and funding rounds.

163
Companies
$715.4M
Total invested
$4.4M
Avg. check
35
Industries
Blockchain 17Decentralized Finance (DeFi) 6Artificial Intelligence (AI) 6Web3 5Cryptocurrency 4Gaming 3+29 more
Founder contacts

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Portfolio companies

Showing 1–24 of 163
Akave
March 2026

Akave is an enterprise cloud infrastructure company that combines blockchain verifiability with S3-compatible object storage.

Bitcoin · Wilmington$6.7M Seed
Haiku
December 2025

Haiku is a DeFi platform that lets users execute complex multi-chain trades and strategies in simple, optimized transactions.

Blockchain · Tórtola$1.0M Pre-Seed
Zoo Finance
December 2025

Zoo Finance a pioneering DeFi protocol focused on unlocking liquidity from locked assets.

Artificial Intelligence (AI) · Hong Kong$8.0M Seed
MegaETH
October 2025

MegaETH is an operator of a blockchain platform for traditional cloud computing servers.

Blockchain · Stanford$50.0M Initial Coin Offering
Yotta Labs
September 2025

Building the GPU Cloud for efficient ML with heterogeneous hardware and cross-cloud orchestration

AI Infrastructure · Seattle$3.5M Seed
BIO Protocol
September 2025

BIO Protocol is a pioneering platform that uses blockchain technology to transform early-stage scientific research finance.

Biotechnology · New York$6.9M Seed
Levr Bet
August 2025

Levr.bet is a leveraged sports betting platform that allows users to place bets.

Blockchain · New Orleans$3.0M Seed
Perle AI
August 2025

Perle AI offers an AI training data platform that provides data solutions at scale for developing specialized AI applications.

Artificial Intelligence (AI) · San Francisco$9.0M Seed
Fermi Labs
May 2025

Fermi Labs is a studio that focuses on researching and developing Web3 technologies.

Blockchain · Weston$1.2M Pre-Seed
CrossCurve Metelayer
April 2025

CrossCurve is a decentralized cross-chain liquidity & data protocol

Blockchain · Tórtola$1.0M Undisclosed
M10
March 2025

Next-gen video game publisher and developer creating truly fresh multiplayer games with player driven economies.

Console Games · London$3.0M Seed
Fortytwo
March 2025

Fortytwo is a decentralized AI network that employs swarm intelligence by linking consumer devices to execute small AI models.

Artificial Intelligence (AI) · Mountain View$2.3M Pre-Seed
Acre
February 2025

Acre provides users with the opportunity to deposit their Bitcoin assets in order to generate additional Bitcoin.

Blockchain · San Francisco$4.0M Venture - Series Unknown
FrodoBots Lab
February 2025

FrodoBots Lab is a pioneer in crowdsourcing robotics data through gaming.

Artificial Intelligence (AI) · Weston$6.0M Seed
Ranger Finance
January 2025

Ranger Finance is perpetual DEX aggregator that offers deep aggregated liquidity, smart order routing, and comprehensive data insight.

Artificial Intelligence (AI) · Singapore$1.9M Seed
Sphere
December 2024

The operating system for stablecoins.

B2B · Boston$5.0M Venture - Series Unknown
Flappy Bird
October 2024

Flappy Bird is a gaming brand that develops games for iOS and Android phones.

Android · Hong Kong$2.0M Seed
Initia Labs
September 2024

Initia is a network for 0-to-1 omnichain rollups built by fusing a novel L1 with an interwoven application-specific L2 infrastructure.

Blockchain · Singapore$14.0M Series A
Octra
September 2024

Octra is an FHE blockchain network that allows for segregated execution environments.

Blockchain · Zug$4.0M Pre-Seed
Open Forest Protocol
September 2024

Open Forest Protocol is building the most transparent monitoring tools and financing mechanisms for nature-based climate solutions.

Blockchain · ZugPre-Seed
zkLink
July 2024

zkLink is a platform that provides application-specific scaling solutions with aggregated liquidity for zk-applications.

Blockchain · SingaporeSeed
Decent Land Labs
June 2024

Researching ways to store, verify, and compute with onchain data

Blockchain · London$3.0M Seed
Versatus
May 2024

Versatus is the development company building VRRB, an innovative blockchain protocol.

Blockchain · MiamiVenture - Series Unknown
Mitosis
May 2024

Mitosis offers an L1 network meant to revolutionize on-chain asset management.

Blockchain · Panama$7.0M Seed

Where Big Brain Holdings invests

Blockchain17
Decentralized Finance (DeFi)6
Artificial Intelligence (AI)6
Web35
Cryptocurrency4
Gaming3

About Big Brain Holdings's portfolio

How many companies has Big Brain Holdings invested in?▸

Big Brain Holdings has invested in 163 companies tracked in our database. The portfolio spans multiple industries and funding stages, from seed-stage startups to late-stage companies.

What industries does Big Brain Holdings invest in?▸

Big Brain Holdings's top investment sectors include Blockchain, Decentralized Finance (DeFi), Artificial Intelligence (AI), Web3, Cryptocurrency. The firm invests across 35 different industry categories.

What is Big Brain Holdings's largest investment?▸

Among tracked funding rounds, MegaETH received $50.0M in a Initial Coin Offering round. Big Brain Holdings's total known invested capital is $715.4M.

What is the average investment size for Big Brain Holdings?▸

Big Brain Holdings's average investment size is $4.4M across its portfolio of 163 companies.

What are Big Brain Holdings's most recent investments?▸

Recent Big Brain Holdings portfolio additions include Akave, Haiku, Zoo Finance, MegaETH, Yotta Labs. These companies were founded in 2020 or later.

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