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Big Brain Holdings — Portfolio, Page 4

Investor actively backing innovative startups and growth-stage companies across various industries and funding rounds.

163
Companies
$593.0M
Total invested
$4.1M
Avg. check
37
Industries
Blockchain 12Cryptocurrency 6Decentralized Finance (DeFi) 6Artificial Intelligence (AI) 6Web3 5Gaming 5+31 more
Founder contacts

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Portfolio companies

Showing 7396 of 163
Jumbo
November 2022

Jumbo is a decentralized exchange platform for automated market markers.

Blockchain · Menlo Park$3.5M Venture - Series Unknown
Layerswap Labs
November 2022

Layerswap Labs is developer of permissionless and trustless bridging protocol.

Cryptocurrency · Middletown$2.5M Pre-Seed
Outdefine
October 2023

Outdefine -- The Learning and Execution Layer For Healthcare Systems.

Generative AI · San Francisco$2.8M Seed
MegaETH
October 2025

MegaETH is an operator of a blockchain platform for traditional cloud computing servers.

Blockchain · Stanford$50.0M Initial Coin Offering
Spice Finance
October 2022

Spice Finance specializes in the fields of financial services.

Cryptocurrency · Berkeley Heights$1.7M Seed
New Computer Corporation
October 2022

New Computer Corporation provides an application program interface for web3 infrastructure.

Software · Los Angeles$2.5M Seed
Flappy Bird
October 2024

Flappy Bird is a gaming brand that develops games for iOS and Android phones.

Android · Hong Kong$2.0M Seed
Derivio
March 2026

Derivio is a trading platform that helps the traders for digital options, DeFi derivative products, and provide provide quick transaction.

Apps$6.0M Seed
Akave
March 2026

Akave is an enterprise cloud infrastructure company that combines blockchain verifiability with S3-compatible object storage.

Bitcoin · Wilmington$6.7M Seed
Haiku
December 2025

Haiku is a DeFi platform that lets users execute complex multi-chain trades and strategies in simple, optimized transactions.

Blockchain · Tórtola$1.0M Pre-Seed
Zoo Finance
December 2025

Zoo Finance a pioneering DeFi protocol focused on unlocking liquidity from locked assets.

Artificial Intelligence (AI) · Hong Kong$8.0M Seed
Kapkap
October 2025

Kapkap is a web3 platform that uses AI for attention based value distribution in gaming.

Artificial Intelligence (AI)$10.0M Seed
Grass
October 2025

Grass is an online community that offers reward for people who provide unused internet for AI developers and enthusiasts.

Artificial Intelligence (AI) · Dublin$10.0M Convertible Note
Yotta Labs
September 2025

Building the GPU Cloud for efficient ML with heterogeneous hardware and cross-cloud orchestration

AI Infrastructure · Seattle$3.5M Seed
Raiku
September 2025

Raiku is a Web3 infrastructure startup focused on enhancing the Solana blockchain's reliability and predictability.

Blockchain · Tallinn$11.3M Seed
BIO Protocol
September 2025

BIO Protocol is a pioneering platform that uses blockchain technology to transform early-stage scientific research finance.

Biotechnology · New York$6.9M Seed
Sonic
September 2025

Sonic provides a blockchain platform for measuring and rewarding user attention and engagement.

Blockchain · San FranciscoSeries Unknown
Levr Bet
August 2025

Levr.bet is a leveraged sports betting platform that allows users to place bets.

Blockchain$3.0M Seed
Inference Labs
June 2025

Inference Labs is advancing the use of zero-knowledge cryptography to guarantee the computational integrity of off-chain AI models.

Artificial Intelligence (AI) · Hamilton$5.3M Seed
Fermi Labs
May 2025

Fermi Labs is a studio that focuses on researching and developing Web3 technologies.

Blockchain · Weston$1.2M Pre-Seed
Optimum
April 2025

Optimum constitutes a decentralized, high-performance memory infrastructure tailored for use across various blockchains.

Blockchain$11.0M Seed
Arcium
March 2025

Arcium is the first parallelized confidential computing network.

Blockchain · Baar$2.0M Angel
M10
March 2025

Next-gen video game publisher and developer creating truly fresh multiplayer games with player driven economies.

Console Games · London$3.0M Seed
Fortytwo
March 2025

Fortytwo is a decentralized AI network that employs swarm intelligence by linking consumer devices to execute small AI models.

Artificial Intelligence (AI) · Mountain View$2.3M Pre-Seed

Where Big Brain Holdings invests

Blockchain12
Cryptocurrency6
Decentralized Finance (DeFi)6
Artificial Intelligence (AI)6
Web35
Gaming5

About Big Brain Holdings's portfolio

How many companies has Big Brain Holdings invested in?

Big Brain Holdings has invested in 163 companies tracked in our database. The portfolio spans multiple industries and funding stages, from seed-stage startups to late-stage companies.

What industries does Big Brain Holdings invest in?

Big Brain Holdings's top investment sectors include Blockchain, Cryptocurrency, Decentralized Finance (DeFi), Artificial Intelligence (AI), Web3. The firm invests across 37 different industry categories.

What is Big Brain Holdings's largest investment?

Among tracked funding rounds, MegaETH received $50.0M in a Initial Coin Offering round. Big Brain Holdings's total known invested capital is $593.0M.

What is the average investment size for Big Brain Holdings?

Big Brain Holdings's average investment size is $4.1M across its portfolio of 163 companies.

What are Big Brain Holdings's most recent investments?

Recent Big Brain Holdings portfolio additions include Jumbo, Layerswap Labs, Outdefine, MegaETH, Spice Finance. These companies were founded in 2020 or later.

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