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Longwood Fund — Portfolio, Page 2

Investor actively backing innovative startups and growth-stage companies across various industries and funding rounds.

55
Companies
$4.0B
Total invested
$80.0M
Avg. check
15
Industries
Biotechnology 20Therapeutics 13Health Care 12Medical 10Life Science 8Pharmaceutical 7+9 more
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Portfolio companies

Showing 2548 of 55
AAVantgarde Bio
November 2025

AAVantgarde Bio is a clinical-stage biotechnology company that develops gene therapies for inherited retinal disorders.

Biotechnology · Milano$141.0M Series B
Vertero
October 2025

Vertero Therapeutics is using cutting-edge research outside of the brain to treat neurodegenerative illnesses.

Biopharma · Woburn$20.0M Series D
Rectify Pharmaceuticals
October 2021

Rectify Pharmaceuticals is a biotechnology company developing Positive Functional Modulators (PFMs), disease-modifying therapeutics.

Biotechnology · Cambridge$100.0M Series A
Mediar Therapeutics
January 2026

Mediar is a pre-clinical stage biotechnology company developing therapeutics for the treatment of fibrosis.

Biotechnology · Cambridge$76.0M Series B
Verastem Oncology
November 2025

Verastem is a biopharmaceutical company developing new medicines to improve the lives of patients with RAS/MAPK pathway-driven cancers.

Biopharma · Needham$90.0M Post Ipo Equity
Crystalys Therapeutics
September 2025

Crystalys Therapeutics is a clinical-stage biopharmaceutical company transforming the treatment of gout.

Biopharma · San Diego$205.0M Series A
KalVista Pharmaceuticals
September 2025

KalVista Pharmaceuticals is an ophthalmology company focused on developing drugs for the treatment of diabetic macular edema (DME).

Biotechnology · Cambridge$125.0M Post Ipo Debt
Solu Therapeutics
April 2025

Solu Therapeutics Platform Company that develops antibody-based medicines using a degradable warhead.

Biotechnology · Boston$41.0M Series A
Newleos Therapeutics
February 2025

Newleos Therapeutics is a biotech startup dedicated to producing safer and more effective neuroscience medicines.

Biotechnology · Boston$93.5M Series A
XyloCor Therapeutics
January 2025

XyloCor Therapeutics is a biopharmaceutical company intended to develop gene therapy for people with coronary artery disease.

Biotechnology · King Of Prussia$67.5M Series B
Interius BioTherapeutics
January 2025

Interius BioTherapeutics is a biotechnology company that delivers genetic medicines for patients.

Biopharma · Philadelphia$21.5M Undisclosed
Progentos Therapeutics
May 2024

Progentos Therapeutics develops an approach to treat multiple sclerosis that stimulates the body's natural repair mechanisms.

Life Science · Watertown$65.0M Series A
Engrail Therapeutics
March 2024

Engrail Therapeutics is a developer of medicines to transform the lives of patients with life-limiting diseases of the nervous system.

Health Care · San Diego$157.0M Series B
Lassen Therapeutics
December 2023

Lassen Therapeutics develops antibody biotherapeutics to help improve the lives of patients suffering from serious diseases.

Biotechnology · San Diego$85.0M Series B
Tome Biosciences
December 2023

Tome Biosciences is a biotechnology company that develops programmable gene insertion technology.

Biotechnology · Watertown$213.0M Series A
Sitryx Therapeutics
September 2023

Sitryx is a biopharmaceutical company develops disease modifying therapeutics in immuno-oncology and immuno-inflammation.

Biotechnology · Oxford$39.0M Series A
Pulmocide
December 2022

Pulmocide is focused on the development of inhaled medicines for the treatment of viral and fungal infections of the respiratory tract.

Biotechnology · London$52.0M Series C
Photys Therapeutics
September 2022

Photys Therapeutics’ proprietary bifunctional small molecules platform unlocks fine-tuned control of protein modifications.

Biotechnology · Cambridge$75.0M Series A
DEM BioPharma
June 2022

DEM BioPharma is an immuno-oncology company that is working to eradicate cancer by targeting novel innate immune system checkpoints.

Biotechnology · Cambridge$70.0M Series A
Carbon Biosciences
June 2022

Carbon Biosciences is a biotech company that engages in the novel parvovirus gene therapy.

Biotechnology · Lexington$38.0M Series A
Calithera Biosciences
March 2022

Calithera Biosciences is a pharmaceutical company developing novel small molecule therapeutics for the treatment of cancer.

Biotechnology · South San Francisco$10.0M Post Ipo Equity
ImmuneID
June 2021

ImmuneID is a precision immunology company that provides a technological platform to deliver insights into the human immune response.

Biotechnology · Boston$50.0M Series A
Renovia
April 2021

Renovia was a developer of prescription digital therapeutics for pelvic floor disorders. Renovia ceased operations in late 2022.

Health Care · Boston$17.0M Series C
Millendo Therapeutics
March 2020

Millendo Therapeutics is a biopharmaceutical company previously primarily focused on developing novel treatments for endocrine diseases.

Biotechnology · Ann Arbor$50.0M Post Ipo Equity

Where Longwood Fund invests

Biotechnology20
Therapeutics13
Health Care12
Medical10
Life Science8
Pharmaceutical7

About Longwood Fund's portfolio

How many companies has Longwood Fund invested in?

Longwood Fund has invested in 55 companies tracked in our database. The portfolio spans multiple industries and funding stages, from seed-stage startups to late-stage companies.

What industries does Longwood Fund invest in?

Longwood Fund's top investment sectors include Biotechnology, Therapeutics, Health Care, Medical, Life Science. The firm invests across 15 different industry categories.

What is Longwood Fund's largest investment?

Among tracked funding rounds, Tome Biosciences received $213.0M in a Series A round. Longwood Fund's total known invested capital is $4.0B.

What is the average investment size for Longwood Fund?

Longwood Fund's average investment size is $80.0M across its portfolio of 55 companies.

What are Longwood Fund's most recent investments?

Recent Longwood Fund portfolio additions include AAVantgarde Bio, Vertero, Rectify Pharmaceuticals, Mediar Therapeutics, Verastem Oncology. These companies were founded in 2020 or later.

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