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RA Capital Management — Portfolio

Investor actively backing innovative startups and growth-stage companies across various industries and funding rounds.

453
Companies
$43.0B
Total invested
$126.1M
Avg. check
24
Industries
Biotechnology 18Health Care 14Pharmaceutical 10Therapeutics 9Medical 7Biopharma 6+18 more
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Portfolio companies

Showing 124 of 453
IO Biotech
September 2025

IO Biotech is a clinical-stage biotech company developing disruptive immune therapies for the treatment of cancer.

Biotechnology · Copenhagen$6.6M Post-IPO Equity
Aktis Oncology
September 2024

Aktis Oncology is a biotechnology company that designs and develops novel class radiopharmaceuticals.

Biotechnology · Boston$175.0M Series B
ARS Pharmaceuticals
September 2025

ARS Pharmaceuticals is a stealth pharmaceutical company that specializes in developing anti allergy drugs.

Biopharma · San Diego$100.0M Post-IPO Debt
Pepgen
September 2025

PepGen is empowering nucleic acid therapeutics to go the distance.

Biotechnology · Oxford$115.0M Post-IPO Equity
KalVista Pharmaceuticals
September 2025

KalVista Pharmaceuticals focuses on developing oral medicines, particularly for managing hereditary angioedema.

Biopharma · Cambridge$125.0M Post-IPO Debt
Monopar
September 2025

Monopar Therapeutics is an emerging biopharmaceutical company focused on developing orphan oncology compounds.

Biopharma · Wilmette$135.0M Post-IPO Equity
Ceribell
September 2022

Ceribell focuses on making electroencephalography accessible, efficient, and cost-effective.

Biotechnology · Mountain View$50.0M Series C
Dignify Therapeutics
September 2024

Dignify Therapeutics is a drug development company focused on delivering novel drug therapies for bladder and bowel disorders in spinal.

Biotechnology · Raleigh$1.2M Grant
HilleVax
September 2023

HilleVax is a biopharmaceutical company that focuses on the development and commercialization of novel vaccines.

Biopharma · Boston$100.0M Post-IPO Equity
Hyku
September 2023

Hyku is a biotech company that develops precise covalent targeting of disease-causing proteins.

Biopharma · Lexington$56.0M Seed
Metalex Commodities
September 2025

Metalex Commodities is a commodity trading company that specializes in the export of metal ores and concentrates.

Precious Metals · Houston$1.4M Grant
Point Biopharma
September 2022

Point Biopharma focused on the development and commercialization of radioligand therapies for the treatment of cancer.

Biopharma · Indianapolis$125.0M Post-IPO Equity
Forge Biologics
September 2022

Forge Biologics is a gene therapy development engine, enabling access to life changing gene therapy programs.

Biotechnology · Grove City$90.0M Series C
Avidity Biosciences
September 2025

Synapse Energy Economics is a consulting firm providing economic and policy analysis for the electric power sector.

Biotechnology · San Diego$690.0M Post-IPO Equity
Navigator Medicines
August 2024

Navigator Medicines operate as a biotech company.

Biotechnology · Scotch Plains$100.0M Series A
Reframe Systems
August 2025

Robotic microfactories for building net-zero homes 2x faster, 2x cheaper with 10x lower carbon

Construction · Andover$20.0M Series A
Plexium
August 2025

Plexium develops a targeted protein degradation platform to find new therapies for cancer and other diseases.

Biotechnology · San Diego$60.1M Series C
Empatica
August 2022

Empatica is an affective computing company focused on human data analytics.

Artificial Intelligence (AI) · Cambridge$25.9M Series B
T-knife
August 2021

T-knife is a developer of T cell receptors intended for T cell therapy of cancer.

Biotechnology · Berlin$110.0M Series B
Arvinas
August 2025

Arvinas advances therapies degrading disease-causing proteins for life-threatening diseases, from discovery to commercialization.

Biotechnology · New HavenPost-IPO Equity
Iterum Therapeutics
August 2025

Iterum Therapeutics is a clinical-stage pharmaceutical company that develops significantly differentiated anti-infectives.

Medical · Dublin$2.2M Post-IPO Equity
GentiBio
August 2021

GentiBio is a biotherapeutics company developing engineered regulatory T cells programmed to treat autoimmune allergic diseases.

Biotechnology · Seattle$157.0M Series A
Sydnexis
August 2021

Sydnexis is engaged in the development of a proprietary treatment for pediatric progressive myopia.

Manufacturing · Del Mar$45.0M Series B
Alchemab Therapeutics
July 2026

Alchemab Therapeutics is developing protective antibodies designed to keep people free of hard-to-treat diseases.

Biotechnology · London$33.6M Series A

Where RA Capital Management invests

Biotechnology18
Health Care14
Pharmaceutical10
Therapeutics9
Medical7
Biopharma6

About RA Capital Management's portfolio

How many companies has RA Capital Management invested in?

RA Capital Management has invested in 453 companies tracked in our database. The portfolio spans multiple industries and funding stages, from seed-stage startups to late-stage companies.

What industries does RA Capital Management invest in?

RA Capital Management's top investment sectors include Biotechnology, Health Care, Pharmaceutical, Therapeutics, Medical. The firm invests across 24 different industry categories.

What is RA Capital Management's largest investment?

Among tracked funding rounds, Avidity Biosciences received $690.0M in a Post-IPO Equity round. RA Capital Management's total known invested capital is $43.0B.

What is the average investment size for RA Capital Management?

RA Capital Management's average investment size is $126.1M across its portfolio of 453 companies.

What are RA Capital Management's most recent investments?

Recent RA Capital Management portfolio additions include IO Biotech, Aktis Oncology, ARS Pharmaceuticals, Pepgen, KalVista Pharmaceuticals. These companies were founded in 2020 or later.

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