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Small Business Innovation Research — Portfolio

Investor actively backing innovative startups and growth-stage companies across various industries and funding rounds.

135
Companies
$156.6M
Total invested
$2.6M
Avg. check
53
Industries
Biotechnology 6Software 6Information Technology 4Education 3Artificial Intelligence (AI) 3Health Care 3+47 more
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Portfolio companies

Showing 124 of 135
StormImpact
September 2023

StormImpact is a Data-driven software designed to keep the utility grid running.

Web Development · Columbus$850K Grant
Sonoran Biosciences
September 2022

Sonoran Biosciences is an early stage pharmaceutical company that has developed SB Gel, the first viscous sustained release carrier.

Biopharma · Scottsdale$260K Grant
Secmation
September 2022

Secmation offers technology, engineering solutions, and tools to integrate information security into industrial and defense products.

Assistive Technology · Raleigh$59K Grant
skillsgapp
September 2024

Skillionaire Games by skillsgapp connects youth to life-changing careers through geolocation-based video games.

Career Planning · Greenville$275K Grant
QubitSolve
September 2025

QubitSolve is developing a software that helps helps engineers in conducting fast and accurate CFD simulations on quantum computers.

Aerospace · Morgantown$1.2M Grant
Ontogen Medtech
September 2022

Ontogen Medtech is a medical device development firm.

Medical Device · Lisle$258K Grant
RiKarbon
August 2024

RiKarbon is a green-tech company that develops renewable products using captured carbon emissions by minimizing waste through innovation.

Green Consumer Goods · Newark$1.1M Grant
TeselaGen
August 2023

TeselaGen Biotechnology develops DNA design and assembly tools for biology.

Artificial Intelligence (AI) · San FranciscoNon-equity Assistance
CoCoPIE
August 2021

CoCoPIE is a startup developing a platform to optimize AI models for edge devices.

Artificial Intelligence (AI) · Irvine$1.1M Series A
Cell Microsystems
August 2023

Cell Microsystems develops, manufactures, and markets innovative products for single-cell biology.

Biotechnology · Durham$6.5M Series B
Kalocyte
August 2023

Kalocyte provides red blood cell substitutes used for trauma care related services.

Biotechnology · Baltimore$5K Grant
IAMBIC
August 2024

AI-driven, precision-fit footwear. A TIME Best Invention of 2023.

Artificial Intelligence (AI) · New York$1.0M Grant
EarthEn
August 2025

EarthEn works on technology to provide a carbon-negative, climate-positive long-duration energy storage solution.

Electrical Distribution · PhoenixNon-equity Assistance
Vestigo Aerospace
August 2022

Vestigo Aerospace provides deorbit capability for cubeSats, small satellites, and launch vehicle stages.

Satellite Communication · La Canada Flintridge$375K Grant
Fluence Analytics
August 2021

Fluence Analytics is a manufacturer of industrial and laboratory systems.

Chemical · New Orleans$7.5M Venture - Series Unknown
Eclipse Regenesis
August 2022

Eclipse Regenesis is a development-stage medical device company focused on harnessing the body’s own tissue regeneration capabilities.

Health Care · Menlo ParkGrant
HC Simulation
August 2021

HC Simulation specializes in products that use the HumMod engine to provide a high-quality simulation of human physiology.

Biotechnology · Canton$237K Grant
Estrigenix Therapeutics
July 2026

Estrigenix is a new pharmaceutical company specializing in oestrogen biology.

Health Care · Milwaukee$2.0M Seed
Specter Aerospace
July 2024

Specter Aerospace is a developer of integrated technology packages.

Aerospace · ClevelandVenture - Series Unknown
2Sigma School
July 2023

2Sigma School provides courses in computer science and data science.

EdTech · Santa Clara$1.0M Grant
gotLearning
July 2025

gotLearning is the creator of LearningPulse and gotFeedback. We help educators in K12 and HE manage qualitative evidence overload.

EdTech · Bryn Mawr$1.3M Grant
Nucleic Sensing Systems
July 2022

Continuous, autonomous, monitoring of eDNA, RNA, and biomolecules to inform management of aquaculture & the environment

Health Diagnostics · Saint Paul$175K Pre-Seed
FarmSense
June 2025

FarmSense develops insect monitoring system.

Electronics · Riverside$1.7M Venture - Series Unknown
Neuroene Therapeutics
June 2024

Neuroene Therapeutics offers novel small molecule mitochondrial therapeutics for epilepsy, Parkinson's Disease, and mitochondrial disease.

Biotechnology · Kensington$400K Grant

Where Small Business Innovation Research invests

Biotechnology6
Software6
Information Technology4
Education3
Artificial Intelligence (AI)3
Health Care3

About Small Business Innovation Research's portfolio

How many companies has Small Business Innovation Research invested in?

Small Business Innovation Research has invested in 135 companies tracked in our database. The portfolio spans multiple industries and funding stages, from seed-stage startups to late-stage companies.

What industries does Small Business Innovation Research invest in?

Small Business Innovation Research's top investment sectors include Biotechnology, Software, Information Technology, Education, Artificial Intelligence (AI). The firm invests across 53 different industry categories.

What is Small Business Innovation Research's largest investment?

Among tracked funding rounds, Fluence Analytics received $7.5M in a Venture - Series Unknown round. Small Business Innovation Research's total known invested capital is $156.6M.

What is the average investment size for Small Business Innovation Research?

Small Business Innovation Research's average investment size is $2.6M across its portfolio of 135 companies.

What are Small Business Innovation Research's most recent investments?

Recent Small Business Innovation Research portfolio additions include StormImpact, Sonoran Biosciences, Secmation, skillsgapp, QubitSolve. These companies were founded in 2020 or later.

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