Skip to main content

Two Sigma Ventures — Portfolio

Investor actively backing innovative startups and growth-stage companies across various industries and funding rounds.

117
Companies
$4.0B
Total invested
$34.0M
Avg. check
67
Industries
Artificial Intelligence (AI) 10Information Technology 5Software 5FinTech 4Cyber Security 4Biopharma 3+61 more
Founder contacts

Verified emails & LinkedIn for founders across this portfolio.

jane@on●●●●●●●.com
linkedin.com/in/●●●●●●
Verified contacts, updated monthly
Get instant access →

Portfolio companies

Showing 1–24 of 117
Hexagon Bio
October 2026

Hexagon Bio discovers and develops new cancer therapies using microbial natural products, genomic data, and artificial intelligence.

Artificial Intelligence (AI) · Menlo Park$62.0M Series C
Nelo
September 2026

Nelo increases the buying power for consumers in LatAm. Backed by Two Sigma Ventures, Homebrew, Susa Ventures, and more.

Finance · Mexico City$100.0M Debt Financing
Artemis
April 2026

Artemis is the first protective layer that is AI-native

Artificial Intelligence (AI) · New York$55.0M Series A
Crossover Markets Group
March 2026

Crossover Markets is a digital asset trading technology company that meets the liquidity requirements of institutional investors.

Finance · London$31.0M Series B
Nullify
February 2026

Nullify is the AI Workforce for Product Security.

Artificial Intelligence (AI) · San Francisco$12.5M Seed
Osmo
February 2026

Osmo gives computers a sense of smell that improves the health and wellbeing of human life.

Artificial Intelligence (AI) · New York$70.0M Series B
Freeform
January 2026

Freeform is a 3D printing company offering metal 3D printing solutions for manufacturing companies.

3D Technology · Los Angeles$58.9M Venture - Series Unknown
Cylera
December 2025

Cylera is a healthcare IoT cybersecurity and intelligence company used to protect healthcare organizations.

Analytics · New YorkConvertible Note
Rive
December 2025

Rive is a real-time animation software provider.

Animation · San Francisco$453K Series A
Cosmos Innovation
November 2025

Cosmos Innovation specialize in full stack software development, product design, cloud hosting, and MVP deployment.

Artificial Intelligence (AI) · SeattleVenture - Series Unknown
Indico Data
October 2025

Indico Data provides machine learning solutions for automating data extraction and analysis from unstructured content.

Analytics · BostonVenture - Series Unknown
Highbeam
September 2025

Banking that helps brand owners make smarter decisions

Business Development · New York$30.0M Series A
Gameto
August 2025

Gameto is a biotechnology company developing therapeutics of the female reproductive system using cell engineering.

Biopharma · New York$44.0M Series C
Dakota Ridge
July 2025

Dakota Ridge is a fintech firm that provides banking services for crypto businesses.

Cryptocurrency · Boulder$12.5M Series A
NetBox Labs
July 2025

NetBox Labs develops services for the open-source NetBox IP address management and data center infrastructure management platform.

Information Technology · New York$35.0M Series B
Cerby
May 2025

Cerby is the identity automation platform for disconnected apps

Cloud Security · San Francisco$40.0M Series B
Compound Eye
May 2025

Compound Eye develops 3D vision systems for autonomous machines.

3D Technology · Redwood City$12.8M Venture - Series Unknown
RightRev
May 2025

RightRev provides software for revenue recognition that helps to track revenue contracts, quote, orders, invoices, and management reporting.

Finance · Santa Clara$13.0M Series A
Steadily
April 2025

Steadily provides property and liability insurance for rental property owners and investors.

Commercial Insurance · Beaverton$30.0M Series C
Freestyle
January 2025

Freestyle is a software development company which builds full stack applications with exceptional infrastructure using typescript.

Apps · San FranciscoSeed
Anomalo
November 2024

Anomalo allows users to continuously inspect and validate the data coming into their warehouses.

Data Management · Palo Alto$10.0M Series B
Candu
November 2024

Candu is a product experience platform for software teams who want to design, refine, and personalize their application’s user interface.

Analytics · San Francisco$3.0M Undisclosed
Terray Therapeutics
October 2024

Terray Therapeutics is a biotechnology company that transforms small molecule drug discovery.

Artificial Intelligence (AI) · Monrovia$120.0M Series B
Distributional
October 2024

Distributional offers a tech platform for enterprise AI testing and evaluation to make AI safe, reliable, and secure.

A/B Testing · Berkeley$19.0M Series A

Where Two Sigma Ventures invests

Artificial Intelligence (AI)10
Information Technology5
Software5
FinTech4
Cyber Security4
Biopharma3

About Two Sigma Ventures's portfolio

How many companies has Two Sigma Ventures invested in?▸

Two Sigma Ventures has invested in 117 companies tracked in our database. The portfolio spans multiple industries and funding stages, from seed-stage startups to late-stage companies.

What industries does Two Sigma Ventures invest in?▸

Two Sigma Ventures's top investment sectors include Artificial Intelligence (AI), Information Technology, Software, FinTech, Cyber Security. The firm invests across 67 different industry categories.

What is Two Sigma Ventures's largest investment?▸

Among tracked funding rounds, Terray Therapeutics received $120.0M in a Series B round. Two Sigma Ventures's total known invested capital is $4.0B.

What is the average investment size for Two Sigma Ventures?▸

Two Sigma Ventures's average investment size is $34.0M across its portfolio of 117 companies.

What are Two Sigma Ventures's most recent investments?▸

Recent Two Sigma Ventures portfolio additions include Hexagon Bio, Nelo, Artemis, Crossover Markets Group, Nullify. These companies were founded in 2020 or later.

Reach the founders behind these 117 companies
Verified emails and LinkedIn profiles, updated monthly.
Get instant access →